pI: 6.0341 |
Length (AA): 898 |
MW (Da): 99608 |
Paralog Number:
4
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 6
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 5 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
4 | 855 | 1wpg (A) | 2 | 994 | 26.00 | 0 | 1 | 1.07 | -0.83 |
13 | 852 | 5ksd (A) | 20 | 844 | 31.00 | 0.00000027 | 1 | 1.24271 | 0.2 |
24 | 846 | 5ksd (A) | 31 | 838 | 39.00 | 0 | 1 | 1.30358 | 0.14 |
105 | 216 | 2hc8 (A) | 214 | 319 | 30.00 | 0.00036 | 0.92 | 0.448822 | 0.09 |
453 | 536 | 2f6u (A) | 1002 | 1090 | 33.00 | 0.1 | 0.83 | 0.372641 | -0.35 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 80-100% percentile | epimastigote, metacyclic. | Smircich P |
Smircich P | Ribosome profiling reveals translation control as a key mechanism generating differential gene expression in Trypanosoma cruzi. |
Ortholog group members (OG5_127253)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT4G11730 | putative plasma membrane-type ATPase |
Arabidopsis thaliana | AT2G18960 | H(+)-ATPase 1 |
Arabidopsis thaliana | AT2G24520 | H(+)-ATPase 5 |
Arabidopsis thaliana | AT3G47950 | H(+)-ATPase 4 |
Arabidopsis thaliana | AT5G57350 | H(+)-ATPase 3 |
Arabidopsis thaliana | AT1G17260 | autoinhibited H(+)-ATPase isoform 10 |
Arabidopsis thaliana | AT5G62670 | H(+)-ATPase 11 |
Arabidopsis thaliana | AT3G60330 | H(+)-ATPase 7 |
Arabidopsis thaliana | AT3G42640 | H(+)-ATPase 8 |
Arabidopsis thaliana | AT2G07560 | H(+)-ATPase 6 |
Arabidopsis thaliana | AT4G30190 | H(+)-ATPase 2 |
Arabidopsis thaliana | AT1G80660 | H(+)-ATPase 9 |
Candida albicans | CaO19.12838 | adenosine triphosphatase |
Candida albicans | CaO19.5383 | adenosine triphosphatase |
Dictyostelium discoideum | DDB_G0268810 | magnesium-translocating P-type ATPase |
Dictyostelium discoideum | DDB_G0282817 | P-type ATPase |
Escherichia coli | b4242 | magnesium transporter |
Leishmania braziliensis | LbrM.18.1740 | P-type H -ATPase, putative |
Leishmania braziliensis | LbrM.18.1550 | P-type H -ATPase, putative |
Leishmania donovani | LdBPK_181510.1 | P-type H+-ATPase 1B, putative |
Leishmania infantum | LinJ.18.1490 | P-type H -ATPase, putative |
Leishmania infantum | LinJ.18.1500 | P-type H -ATPase, putative |
Leishmania infantum | LinJ.18.1510 | P-type H -ATPase, putative |
Leishmania major | LmjF.18.1510 | P-type H -ATPase, putative |
Leishmania major | LmjF.18.1520 | P-type H -ATPase, putative |
Leishmania mexicana | LmxM.18.1510 | P-type H -ATPase, putative |
Leishmania mexicana | LmxM.18.1520 | P-type H -ATPase, putative |
Neospora caninum | NCLIV_022240 | ATPase, related |
Oryza sativa | 4331853 | Os03g0183900 |
Oryza sativa | 4337257 | Os04g0656100 |
Oryza sativa | 4342621 | Os07g0191200 |
Oryza sativa | 4331015 | Os02g0797300 |
Oryza sativa | 4331281 | Os03g0100800 |
Oryza sativa | 4333770 | Os03g0689300 |
Oryza sativa | 4340312 | Os06g0181500 |
Oryza sativa | 4352910 | Os12g0638700 |
Oryza sativa | 4338405 | Os05g0319800 |
Saccharomyces cerevisiae | YPL036W | H(+)-exporting P2-type ATPase PMA2 |
Saccharomyces cerevisiae | YGL008C | H(+)-exporting P2-type ATPase PMA1 |
Trypanosoma brucei gambiense | Tbg972.10.15070 | P-type H -ATPase, putative |
Trypanosoma brucei | Tb927.10.12510 | P-type H+-ATPase, putative |
Trypanosoma brucei | Tb927.10.12500 | P-type H+-ATPase, putative |
Trypanosoma congolense | TcIL3000_10_10700 | P-type H+-ATPase, putative |
Trypanosoma cruzi | TcCLB.506333.10 | plasma-membrane proton-efflux P-type ATPase, putative |
Trypanosoma cruzi | TcCLB.510575.5 | proton motive ATPase, putative |
Trypanosoma cruzi | TcCLB.505763.19 | P-type H+-ATPase, putative |
Trypanosoma cruzi | TcCLB.505763.10 | proton motive ATPase 1, putative |
Trypanosoma cruzi | TcCLB.506649.20 | P-type H+-ATPase, putative |
Toxoplasma gondii | TGME49_252640 | P-type ATPase PMA1 |
Toxoplasma gondii | TGME49_284602 | E1-E2 ATPase subfamily protein |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.10.12510 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
Tb927.10.12510 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb927.10.12510 | Trypanosoma brucei | significant loss of fitness in procyclic forms | alsford |
Tb927.10.12510 | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
Tb927.10.12500 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
Tb927.10.12500 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb927.10.12500 | Trypanosoma brucei | significant loss of fitness in procyclic forms | alsford |
Tb927.10.12500 | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
b4242 | Escherichia coli | non-essential | goodall |
YGL008C | Saccharomyces cerevisiae | inviable | yeastgenome |
TGME49_284602 | Toxoplasma gondii | Probably non-essential | sidik |
TGME49_252640 | Toxoplasma gondii | Probably non-essential | sidik |
TGME49_284602 | Toxoplasma gondii | Essentiality uncertain | sidik |
TGME49_252640 | Toxoplasma gondii | Essentiality uncertain | sidik |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
Affected Entity | Phenotypic quality | Occurs in | Occurs at | Evidence | Observed in | Drugs/Inhibitors |
---|---|---|---|---|---|---|
growth (GO:0040007) | decreased (PATO:0000468) | epimastigote (BTO:0000409) | inferred from in vitro culture assay (ECO:0000182) | Trypanosoma cruzi | 89491 546930 | |
Annotator: | millerja@u.washington.edu. | Comment: | Note: manuscript suggested mode of action against proton-translocating, membrane-localized ATPases (H+-ATPases); surveyed GeneDB and selected four genes that most closely matched this description. Link perhaps too weak to include?. | References: | 10103219 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Druggability index (range: 0 to 1): 0.5
Compound | Source | Reference |
---|---|---|
Curated by TDRTargets | References | |
Curated by TDRTargets | References |
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Trypanosoma cruzi | P-type H+-ATPase, putative | Compounds | References |
Species | Target | Length | Identity | Alignment span | Linked Drugs | Reference |
---|---|---|---|---|---|---|
Trypanosoma cruzi | P-type H+-ATPase, putative | 259 aa | 75.1% | 225 aa | Compounds | References |
1 literature reference was collected for this gene.